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A package with the NDC: 76439-103-10 contains the same medication as a package with which of the following NDCs?
TheNational Drug Code (NDC)is a unique 10- or 11-digit number assigned to each drug product in the U.S.Understanding how NDC numbers are structuredis key to answering this question correctly.
The NDC format is as follows:XXXXX-YYYY-ZZ
First segment (XXXXX)Labeler (Manufacturer or Distributor)
Second segment (YYYY)Product Code (Specific Drug, Strength, and Formulation)
Third segment (ZZ)Package Size (Quantity in the Package)
How to Find the Correct Answer?The given NDC:76439-103-10
76439= Manufacturer/Labeler Code
103= Product Code (Specific Drug & Strength)
10= Package Size
To matchthe same medication, theManufacturer (76439) and Product Code (103) must remain the same. Only thepackage size (last segment) can change.
A . 76439-208-10Incorrect
Product Code (208) does not match (103).
B . 76439-103-50Correct
Same manufacturer (76439) and same drug (103), but different package size (50 instead of 10).
C . 74693-103-10Incorrect
Different manufacturer (74693 instead of 76439).
D . 74693-206-50Incorrect
Different manufacturer (74693) and different product code (206).
FDA NDC Directory-- Provides details on NDC structure and product identification.
PTCB PTCE Exam Content Outline-- Covers NDC interpretation and drug identification.
Drug Supply Chain Security Act (DSCSA)-- Reinforces correct medication identification using NDC.
Analyzing the Answer Choices:Key Reference:
Thegeneric namefor5-FUis:
5-FU (Fluorouracil) is a chemotherapy drugused forcolon, breast, and skin cancers.
It is apyrimidine analogthatprevents cancer cell DNA replication.
Why Other Options Are Incorrect:
A . Fluocinonide?Topical corticosteroid for skin conditions.
B . Fluoxetine (Prozac)?SSRI antidepressant.
C . Fluocinolone?Topical corticosteroid.
Reference:National Cancer Institute Chemotherapy Guide, PTCB Oncology Medications.
If M-M-R II antigen were inadvertently reconstituted with a stock vial of normal saline, pharmacy staff should:
TheM-M-R II (Measles, Mumps, and Rubella) vaccinemust bereconstituted only with the manufacturer-supplied diluentto maintain its efficacy and stability.
The manufacturer-provided diluent contains stabilizing agents that preserve the live attenuated virus.
Using normal saline can alter the pH and degrade the vaccine, making it ineffective.
The vaccine must be discarded if reconstituted incorrectlyand not administered.
A . Administer the vaccine as the diluents are equivalent.Incorrect
Normal saline is NOT equivalent to the manufacturer's diluentand can compromise the vaccine's potency.
B . Report the incident to the Drug Enforcement Administration (DEA).Incorrect
Vaccine errors should be reported to the CDC's Vaccine Adverse Event Reporting System (VAERS), not the DEA(which handles controlled substances, not vaccines).
C . Contact the Environmental Protection Agency (EPA) for guidance.Incorrect
The EPA regulates hazardous waste, not vaccine errors.The CDC or vaccine manufacturer should be contacted for guidance.
CDC Vaccine Storage and Handling Guidelines-- States thatvaccines must be reconstituted only with manufacturer-supplied diluents.
FDA Guidelines for M-M-R II Vaccine-- Confirms that improper reconstitutionrenders the vaccine ineffective.
PTCB PTCE Exam Content Outline-- Covers proper vaccine handling and error prevention.
Why Is Normal Saline Not an Acceptable Diluent?Why Not the Other Options?Key Reference:
What type ofmedication erroris described asa mistake in prescribing, dispensing, or planned medication administration that is detected and corrected before reaching the patient?
A potential error is a mistake that is identified and corrected before it reaches the patient.
Example:A technician fillshydralazineinstead ofhydroxyzine, but the pharmacist catches the mistake before dispensing.
Reference:ISMP Medication Error Categories, PTCE Pharmacy Error Prevention Guide.
How many2 oz bottlescan be filled if100 mL of a 20% solutionis diluted to make a2% solution?
Dilution formula:CV = CV
C = 20%, V = 100 mL, C = 2%
(20)(100) = (2)(V) V = 1000 mL(final volume after dilution).
Convert to oz:1000 mL 59 mL (2 oz) = 16 bottles.
Reference:PTCE Pharmacy Dilution Calculations, USP <795> Guidelines.
